Read an interesting article on conceptual personal knowledge management software. The approach is interesting but I think it represents too huge of a paradigm shift for most people. My experience is these things have to aclimate gradually to the masses. Either way, Dave Pollard's (the author) view is an interesting one and worthy of additional research. Heres the link for further reading:

http://blogs.salon.com/0002007/2004/02/26.html#a642

also a good reference for other generalized "knowledge work:"
http://www.kwork.org/